Biomarkers of medullary thyroid cancer
Biomarkers of medullary thyroid cancer
AfkhamizadehM.
Assistant professor of endocrinology , Mashhad University of Medical Sciences
SECRETORY PRODUCTS OF MTC
- Adrenocorticotropic hormone(ACTH)
- B-melanocyte stimulating hormone
- Calcitonin( Ctn)*
-
- specific biomarker for the diagnosis of C-cell hyperplasia or MTC
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- Carcinoembryonic antigen (CEA)
- Chromogranin
- Neurotensin
- Somatostatin
- *Kihara M, Miyauchi A, Kudo T, et al (2016). Reference values of serum calcitonin with calcium stimulation tests by electrochemiluminescence immunoassay before/after total thyroidectomy in Japanese patients with thyroid diseases other than medullary thyroid carcinoma. Endocr J, 63, 627-32.
Main biomarkers of MTC
Calcitonin
Basal serum calcitonin
Correlate with tumor mass
almost always high in patients with a palpable tumor
Reflect tumor differentiation*
Overlap between MTC and CCH**
Calcitonin stimulation test
Pentagastrin
Calcium
CEA:
Useful for evaluating disease progression in patients following thyroidectomy as accessory marker
Procalcitonin
High procalcitonin to Ctn ratio is useful in predicting prognosis
A marked elevation in the serum CEA level out of proportion to a lower serum Ctn level or normal or low levels of both serum Ctn and CEA indicate poorly differentiated MTC
*Medullary thyroid carcinoma.Pacini F, Castagna MG, Cipri C, Schlumberger M. Clin Oncol (R Coll Radiol) 2010; 22:475.
**Papadakis G1, Keramidas I2, Triantafillou E2, Kanouta F2, Pappa T2, Kaltzidou V2, Tertipi A2, Iordanidou L3, Trivizaki E3, Vecchini G4, Villiotou V5, Pappas A2.Association of Basal and Calcium-stimulated Calcitonin Levels with Pathological Findings After Total Thyroidectomy. Anticancer Res. 2015 Jul;35(7):4251-8.
